Browsing by Subject "natural product"

Now showing items 1-4 of 4

    • Biosynthesis and Cellular Actions of Bioactive Natural Products 
      Mori, Shogo (2015-12-12)
      The utilization of natural products as therapeutic agents has been an invaluable resource throughout medicinal history. Through the combined application of combinatorial biosynthesis, the modification of a natural product ...
    • Investigation of the Azinomycin Biosynthetic Pathway 
      Washburn, Lauren Ashley (2020-05-18)
      The azinomycins are hybrid nonribosomal peptide and polyketide natural products isolated from Streptomyces sahachiroi. They are of interest due to their antitumor and broad antibiotic activity, which comes from the ability ...
    • Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation 
      Foulke-Abel, Jennifer (2012-02-14)
      Biosynthetic natural products are invaluable resources that have been gleaned from the environment for generations, and they play an essential role in drug development. Natural product biosynthesis also possesses the latent ...
    • Probing the Biosynthesis and Mode of Action of Azinomycin B 
      Kelly, Gilbert Thomson (2010-10-12)
      Since the isolation of azinomycins A and B in 1954 from the soil bacterium, Streptomyces sahachiroi, these natural products have been synthetic targets. Both compounds exhibit in vitro cytotoxic activity at submicromolar ...